Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium.

@article{Vanoverschelde1993MechanismsOC,
  title={Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium.},
  author={Jean-Louis Vanoverschelde and Williams Wijns and Christophe Depr{\'e} and B. Essamri and Guy R. Heyndrickx and Marcel Borgers and Anne Bol and Jacques A. Melin},
  journal={Circulation},
  year={1993},
  volume={87 5},
  pages={
          1513-23
        }
}
BACKGROUND Even in the absence of a previous myocardial infarction, patients with coronary artery disease often present with chronic regional wall motion abnormalities that are reversible spontaneously or after coronary revascularization. In these patients, regional dysfunction has been proposed to result either from prolonged postischemic dysfunction (myocardial "stunning") or from adaptation to chronic hypoperfusion (myocardial "hibernation"). This study examines which of these two mechanisms… CONTINUE READING

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