Mechanisms of chromosomal translocations in B cell lymphomas

@article{Kppers2001MechanismsOC,
  title={Mechanisms of chromosomal translocations in B cell lymphomas},
  author={Ralf K{\"u}ppers and Riccardo Dalla‐Favera},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={5580-5594}
}
Reciprocal chromosomal translocations involving the immunoglobulin (Ig) loci are a hallmark of most mature B cell lymphomas and usually result in dysregulated expression of oncogenes brought under the control of the Ig enhancers. Although the precise mechanisms involved in the development of these translocations remains essentially unknown, a clear relationship has been established with the mechanisms that lead to Ig gene remodeling, including V(D)J recombination, isotype switching and somatic… Expand
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