Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.

@article{Burke2007MechanismsOC,
  title={Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.},
  author={Angela S Burke and Kelly R. Redeker and Richard C. Kurten and Laura P. James and Jack A. Hinson},
  journal={Journal of toxicology and environmental health. Part A},
  year={2007},
  volume={70 22},
  pages={1936-45}
}
The role of mitochondrial permeability transition (MPT) and oxidative stress in chloroform toxicity was determined in freshly isolated female B6C3F1 mouse hepatocytes. Incubation of chloroform (12 mM) with hepatocytes resulted in cell death (alanine aminotransferase release and propidium iodide fluorescence). Chloroform had volatilized from the incubation… CONTINUE READING