Mechanisms of chloride transport in thymic lymphocytes.

  title={Mechanisms of chloride transport in thymic lymphocytes.},
  author={D Stakisaitis and Michael J. Lapointe and Daniel Batlle},
  journal={American journal of physiology. Renal physiology},
  volume={280 2},
This study examined mechanisms of Cl- transport in rat lymphocytes under a variety of conditions. Basal intracellular Cl- concentration ([Cl-]i) was not different between cells assayed in the presence of HCO3- or its absence (HEPES). Removal of external Cl- resulted in a fall in [Cl-]i and a rapid rise in intracellular pH (pH(i)). Both Cl- efflux and the rise in pH(i) were blocked by DIDS or removal of external Na+ but were unaffected by furosemide. The mechanisms governing Cl- influx were… CONTINUE READING