Mechanisms of chemical toxicity--a unifying hypothesis.

  • Dennis V. Parke
  • Published 1982 in Regulatory toxicology and pharmacology : RTP

Abstract

Most cases of chemical toxicity involve one or both of the fundamental pathological processes of "acute lethal injury" and "autoxidative cellular injury." The process of "acute lethal injury" by which toxic chemicals interfere with cellular energy metabolism, leading ultimately to cell death and tissue necrosis, is well known and reasonably understood… (More)

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