Mechanisms of chemical-induced innate immunity in allergic contact dermatitis.

@article{Martin2011MechanismsOC,
  title={Mechanisms of chemical-induced innate immunity in allergic contact dermatitis.},
  author={Stefan F Martin and Philipp R Esser and Felix C. Weber and Thilo Jakob and Marina A. Freudenberg and M. F. Schmidt and Matthias Goebeler},
  journal={Allergy},
  year={2011},
  volume={66 9},
  pages={1152-63}
}
Allergic contact dermatitis (ACD) is one of the most prevalent occupational skin diseases and causes severe and long-lasting health problems in the case of chronification. It is initiated by an innate inflammatory immune response to skin contact with low molecular weight chemicals that results in the priming of chemical-specific, skin-homing CD8(+) Tc1/Tc17 and CD4(+) Th1/Th17 cells. Following this sensitization step, T lymphocytes infiltrate the inflamed skin upon challenge with the same… CONTINUE READING

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