Mechanisms of cellular penetration and nuclear localization of an anti-double strand DNA autoantibody.

@article{Zack1996MechanismsOC,
  title={Mechanisms of cellular penetration and nuclear localization of an anti-double strand DNA autoantibody.},
  author={Debra Jeske Zack and M Stempniak and Andrew L Wong and Claire Taylor and Richard H. Weisbart},
  journal={Journal of immunology},
  year={1996},
  volume={157 5},
  pages={2082-8}
}
An anti-dsDNA Ab, mAb 3E10, was identified that bound membranes of fixed human renal tubular cells, penetrated live murine renal tubular cells in vivo, and localized in the cell nucleus. mAb 3E10 binds both dsDNA and an extracellular matrix protein, HP8/HEVIN, expressed in high endothelial venules. Previous studies showed both shared and distinct binding determinants of mAb 3E10 VH for DNA and HP8/HEVIN. To independently assess the requirement of DNA and HP8/HEVIN in cellular penetration, site… CONTINUE READING
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