Mechanisms of cell death induced by the neutrophil antimicrobial peptides alpha-defensins and LL-37.

@article{Aarbiou2006MechanismsOC,
  title={Mechanisms of cell death induced by the neutrophil antimicrobial peptides alpha-defensins and LL-37.},
  author={Jamil Aarbiou and Geuranne S. Tjabringa and Renate M. Verhoosel and Dennis K. Ninaber and Steven R White and Lucy T. C. Peltenburg and Klaus Friedrich Rabe and Pieter S Hiemstra},
  journal={Inflammation research : official journal of the European Histamine Research Society ... [et al.]},
  year={2006},
  volume={55 3},
  pages={119-27}
}
OBJECTIVE The aim of this study was to investigate the mechanisms of cell death mediated by the antimicrobial peptides neutrophil defensins (human neutrophil peptides 1-3 [HNP1-3]) and LL-37. MATERIALS AND METHODS HNP1-3- and LL-37-mediated cell death was assessed in human lung epithelial cells and Jurkat T-cells in serum-free culture media. RESULTS Both HNP1-3 and LL-37 induced cell death in Jurkat T-cells and A549 cells. HNP1-3 but not LL-37 induced caspase-3/-7 activity and caused… CONTINUE READING
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