Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy.

@article{Mendes2005MechanismsOC,
  title={Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy.},
  author={Hugo F. Mendes and Jacqueline van der Spuy and J. Paul Chapple and Michael E Cheetham},
  journal={Trends in molecular medicine},
  year={2005},
  volume={11 4},
  pages={
          177-85
        }
}
Retinitis pigmentosa (RP) is a group of retinal degenerative diseases that are characterised primarily by the loss of rod photoreceptor cells. Mutations in rhodopsin are the most common cause of autosomal-dominant RP (ADRP). Here, we propose a new classification for rhodopsin mutations based on their biochemical and cellular properties. Several different potential gain-of-function mechanisms for rhodopsin ADRP are described and discussed. Possible dominant-negative mechanisms, which affect the… CONTINUE READING
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