Mechanisms of cell activation by heavy metal ions.

@article{Wagner1998MechanismsOC,
  title={Mechanisms of cell activation by heavy metal ions.},
  author={Mathias Wagner and Christina L. Klein and Theo G van Kooten and C James Kirkpatrick},
  journal={Journal of biomedical materials research},
  year={1998},
  volume={42 3},
  pages={
          443-52
        }
}
Heavy metal ions can be released by corroding metallic implants into the surrounding tissue. When they enter blood vessels some of them are carried by proteins like albumin and can be taken up by endothelial cells lining the vessels. To study their involvement in the inflammatory response we investigated heavy metal ion induced effects in cultured human vascular endothelial cells (HUVECs). NiCl2 and CoCl2 upregulate, especially in concentrations of 1 mM, the expression of adhesion molecules (e… CONTINUE READING
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