Mechanisms of caspase activation and inhibition during apoptosis.

@article{Shi2002MechanismsOC,
  title={Mechanisms of caspase activation and inhibition during apoptosis.},
  author={Yigong Shi},
  journal={Molecular cell},
  year={2002},
  volume={9 3},
  pages={
          459-70
        }
}
Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents our current understanding of caspase regulation during apoptosis. 
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