Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury.

@article{Nossuli1998MechanismsOC,
  title={Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury.},
  author={Tareck O Nossuli and Reid Hayward and David E. Jensen and Rosario G Scalia and Allan M. Lefer},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1998},
  volume={275 2},
  pages={H509-H519}
}
Peroxynitrite (ONOO-), an intermediate formed from the equimolar interaction of nitric oxide (NO) and superoxide, is thought to be an important mediator of tissue injury in myocardial ischemia-reperfusion. However, physiologically relevant (i.e., maximally achievable) concentrations of ONOO- significantly decreased neutrophil-endothelium interactions in the rat mesentery. We therefore examined the dose-response relationship of infusion of different concentrations of ONOO- in a feline model of… CONTINUE READING
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