Mechanisms of cardiac and renal dysfunction in patients dying of sepsis.

  title={Mechanisms of cardiac and renal dysfunction in patients dying of sepsis.},
  author={Osamu Takasu and Joseph P. Gaut and Eizo Watanabe and Kathleen B. To and Richard E Fagley and Brian K. Sato and Steve Jarman and Igor R. Efimov and Deborah L. Janks and Anil Srivastava and Sam B. Bhayani and Anne M. Drewry and Paul E. Swanson and Richard S Hotchkiss},
  journal={American journal of respiratory and critical care medicine},
  volume={187 5},
RATIONALE The mechanistic basis for cardiac and renal dysfunction in sepsis is unknown. In particular, the degree and type of cell death is undefined. OBJECTIVES To evaluate the degree of sepsis-induced cardiomyocyte and renal tubular cell injury and death. METHODS Light and electron microscopy and immunohistochemical staining for markers of cellular injury and stress, including connexin-43 and kidney-injury-molecule-1 (Kim-1), were used in this study. MEASUREMENTS AND MAIN RESULTS Rapid… CONTINUE READING
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  • JP Gaut, O Takasu, PE Swanson, RS. Hotchkiss
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