Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus.

@article{Hoffman2000MechanismsOC,
  title={Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus.},
  author={Alexander F Hoffman and Carl R. Lupica},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 7},
  pages={2470-9}
}
The localization of cannabinoid (CB) receptors to GABAergic interneurons in the hippocampus indicates that CBs may modulate GABAergic function and thereby mediate some of the disruptive effects of marijuana on spatial memory and sensory processing. To investigate the possible mechanisms through which CB receptors may modulate GABAergic neurotransmission in the hippocampus, whole-cell voltage-clamp recordings were performed on CA1 pyramidal neurons in rat brain slices. Stimulus-evoked GABA(A… CONTINUE READING
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