Mechanisms of cancer metastasis to the bone

Abstract

ABSTRACTSome of the most common human cancers, including breast cancer, prostate cancer, and lung cancer, metastasize with avidity to bone. What is the basis for their preferential growth within the bone microenvironment? Bidirectional interactions between tumor cells and cells that make up bone result in a selective advantage for tumor growth and can lead… (More)
DOI: 10.1038/sj.cr.7290266

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