Mechanisms of cancer-induced hypercalcemia.

  title={Mechanisms of cancer-induced hypercalcemia.},
  author={Thomas J Rosol and Charles Chabert Capen},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={67 6},
Cancer-associated hypercalcemia is due to the: (a) elaboration of systemically-acting humoral factors by neoplasms which alter calcium metabolism in bone, kidney, and intestine; or (b) stimulation of bone resorption at sites of tumor metastasis to bone. It is likely that both mechanisms occur in the same patient with certain neoplasms. There are many humoral factors that can be produced by tumors, secreted into the circulation, and have distant effects which induce hypercalcemia. The… CONTINUE READING