Mechanisms of cadmium toxicity in terrestrial pulmonates: programmed cell death and metallothionein overload.

  title={Mechanisms of cadmium toxicity in terrestrial pulmonates: programmed cell death and metallothionein overload.},
  author={M. Chabicovsky and W. Klepal and R. Dallinger},
  journal={Environmental toxicology and chemistry},
  volume={23 3},
A sublethal dose of cadmium (Cd2+) administered via the diet during short-term exposure over 10 d induced programmed cell death in the hepatopancreas of the terrestrial pulmonate snail Helix pomatia. Condensed cell residues were predominantly phagocytosed by calcium cells, suggesting a specific function of these epithelial cells in metal detoxification or in clearing the organ of cellular debris from cell death. The considerable cell loss recorded by histological analysis was accompanied by… Expand
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