Mechanisms of breathing instability in patients with obstructive sleep apnea.

@article{Younes2007MechanismsOB,
  title={Mechanisms of breathing instability in patients with obstructive sleep apnea.},
  author={M. R. Younes and Michele Ostrowski and Raj S Atkar and John Laprairie and Andrea Siemens and Patrick J. Hanly},
  journal={Journal of applied physiology},
  year={2007},
  volume={103 6},
  pages={1929-41}
}
The response to chemical stimuli (chemical responsiveness) and the increases in respiratory drive required for arousal (arousal threshold) and for opening the airway without arousal (effective recruitment threshold) are important determinants of ventilatory instability and, hence, severity of obstructive apnea. We measured these variables in 21 obstructive apnea patients (apnea-hypopnea index 91 +/- 24 h(-1)) while on continuous-positive-airway pressure. During sleep, pressure was… CONTINUE READING
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