Mechanisms of bradykinin-mediated dilation in newborn piglet pulmonary conducting and resistance vessels.

@article{Aschner2002MechanismsOB,
  title={Mechanisms of bradykinin-mediated dilation in newborn piglet pulmonary conducting and resistance vessels.},
  author={Judy L Aschner and Thuy K. Smith and N{\'o}ra Kov{\'a}cs and Joaquim M B Pinheiro and Mamta Fuloria},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={283 2},
  pages={L373-82}
}
Bradykinin (BK) is a potent dilator of the perinatal pulmonary circulation. We investigated segmental differences in BK-induced dilation in newborn pig large conducting pulmonary artery and vein rings and in pressurized pulmonary resistance arteries (PRA). In conducting pulmonary arteries and veins, BK-induced relaxation is abolished by endothelial disruption and by inhibition of nitric oxide (NO) synthase with nitro-L-arginine (L-NA). In PRA, two-thirds of the dilation response is L-NA… CONTINUE READING