Mechanisms of bradykinin-induced cerebral vasodilatation in rats. Evidence that reactive oxygen species activate K+ channels.

@article{Sobey1997MechanismsOB,
  title={Mechanisms of bradykinin-induced cerebral vasodilatation in rats. Evidence that reactive oxygen species activate K+ channels.},
  author={Christopher G Sobey and Donald D. Heistad and Frank M. Faraci},
  journal={Stroke},
  year={1997},
  volume={28 11},
  pages={2290-4; discussion 2295}
}
BACKGROUND AND PURPOSE Relatively little is know regarding mechanisms by which reactive oxygen species produce dilatation of cerebral arterioles. The goal of this study was to test the hypothesis that vasodilator responses of cerebral arterioles to bradykinin, which produces endogenous generation of reactive oxygen species, involve activation of calcium-dependent potassium channels. METHODS We used a cranial window in anesthetized rats to examine effects of catalase (which degrades hydrogen… CONTINUE READING

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