Mechanisms of bovine herpesvirus type 1 neutralization by monoclonal antibodies to glycoproteins gI, gIII and gIV.

@article{Dubuisson1992MechanismsOB,
  title={Mechanisms of bovine herpesvirus type 1 neutralization by monoclonal antibodies to glycoproteins gI, gIII and gIV.},
  author={Jean Dubuisson and Babara A Israel and Geoffrey J. Letchworth},
  journal={The Journal of general virology},
  year={1992},
  volume={73 ( Pt 8)},
  pages={2031-9}
}
We examined a panel of monoclonal antibodies (MAbs) against bovine herpesvirus type 1 (BHV-1) glycoproteins gI, gIII and gIV for inhibition of virus attachment and interference with subsequent steps of infection. Attachment of radiolabelled virions was partially prevented by 600 to 700 micrograms/ml of IgM antibodies against gI and gIII and one IgG2A antibody against gIV, but not by the majority of MAbs against any of the three viral glycoproteins. Productive infection following attachment was… CONTINUE READING