Mechanisms of bone resorption in myeloma.

  title={Mechanisms of bone resorption in myeloma.},
  author={Garson David Roodman},
  journal={Journal of musculoskeletal & neuronal interactions},
  volume={3 4},
  pages={271-2; discussion 292-4}
Bone destruction is very common in myeloma and occurs in over 80% of patients. It is responsible for some of the most devastating complications of the disease including pathologic fractures, bone pain and hypercalcemia. However, the mechanisms responsible for bone destruction in myeloma and the inability of the osteoblast to repair bone lesions even when the disease is in clinical remission remain unknown. Several factors have been implicated in the bone destructive process in myeloma including… CONTINUE READING


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