Mechanisms of bone metastases of breast cancer.

  title={Mechanisms of bone metastases of breast cancer.},
  author={Larry J. Suva and Robert J. Griffin and Issam Makhoul},
  journal={Endocrine-related cancer},
  volume={16 3},
Cancer development is a multi-step process driven by genetic alterations that elicit the progressive transformation of normal human cells into highly malignant derivatives. The altered cell proliferation phenotype of cancer involves a poorly characterized sequence of molecular events, which often result in the development of distant metastasis. In the case of breast cancer, the skeleton is among the most common of metastatic sites. In spite of its clinical importance, the underlying cellular… CONTINUE READING

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