Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi's sarcoma-associated herpesvirus protein ORF45.

@article{Sathish2011MechanismsOA,
  title={Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi's sarcoma-associated herpesvirus protein ORF45.},
  author={Narayanan Sathish and Fan Xiu Zhu and Ellis E. Golub and Qiming Liang and Yan Yuan},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 1},
  pages={746-56}
}
IRF-7 is the master regulator of type I interferon-dependent immune responses controlling both innate and adaptive immunity. Given the significance of IRF-7 in the induction of immune responses, many viruses have developed strategies to inhibit its activity to evade or antagonize host antiviral responses. We previously demonstrated that ORF45, a KSHV immediate-early protein as well as a tegument protein of virions, interacts with IRF-7 and inhibits virus-mediated type I interferon induction by… CONTINUE READING