Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid.

  title={Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid.},
  author={Bernard J Fisher and Donatas Kraskauskas and Erika J Martin and Daniela Farkas and Jacob A. Wegelin and Donald F. Brophy and Kevin R. Ward and Norbert Felix Voelkel and Alpha A Berry Fowler and Ramesh Natarajan},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={303 1},
Bacterial infections of the lungs and abdomen are among the most common causes of sepsis. Abdominal peritonitis often results in acute lung injury (ALI). Recent reports demonstrate a potential benefit of parenteral vitamin C [ascorbic acid (AscA)] in the pathogenesis of sepsis. Therefore we examined the mechanisms of vitamin C supplementation in the setting of abdominal peritonitis-mediated ALI. We hypothesized that vitamin C supplementation would protect lungs by restoring alveolar epithelial… 

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