Mechanisms of apoptosis after ischemia and reperfusion: Role of the renin-angiotensin system

@article{Kossmehl2006MechanismsOA,
  title={Mechanisms of apoptosis after ischemia and reperfusion: Role of the renin-angiotensin system},
  author={Peter Walter Kossmehl and E J Kurth and Shideh Faramarzi and Britta Habighorst and Mehdi Shakibaei and Markus Wehland and Reinhold Kreutz and Manfred Infanger and A. H. Jan Danser and Jirka Grosse and Martin Paul and Daniela Grimm},
  journal={Apoptosis},
  year={2006},
  volume={11},
  pages={347-358}
}
Background: Apoptosis plays a key role in the pathogenesis of cardiac diseases. We examined the influence of the renin-angiotensin system (RAS) on different regulators of apoptosis using an isolated hemoperfused working porcine heart model of acute ischemia (2 h), followed by reperfusion (4 h). Methods and Results: 23 porcine hearts were randomized to 5 groups: hemoperfused non-infarcted hearts (C), infarcted hearts (MI: R. circumflexus), infarcted hearts treated with quinaprilat (Q), infarcted… 
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