Mechanisms of apoptosis after ischemia and reperfusion: Role of the renin-angiotensin system

  title={Mechanisms of apoptosis after ischemia and reperfusion: Role of the renin-angiotensin system},
  author={Peter Walter Kossmehl and E J Kurth and Shideh Faramarzi and Britta Habighorst and Mehdi Shakibaei and Markus Wehland and Reinhold Kreutz and Manfred Infanger and A. H. Jan Danser and Jirka Grosse and Martin Paul and Daniela Grimm},
Background: Apoptosis plays a key role in the pathogenesis of cardiac diseases. We examined the influence of the renin-angiotensin system (RAS) on different regulators of apoptosis using an isolated hemoperfused working porcine heart model of acute ischemia (2 h), followed by reperfusion (4 h). Methods and Results: 23 porcine hearts were randomized to 5 groups: hemoperfused non-infarcted hearts (C), infarcted hearts (MI: R. circumflexus), infarcted hearts treated with quinaprilat (Q), infarcted… 
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Expression of vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia/reperfusion injury.
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    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • 2007
Potential Role of Renin-Angiotensin System Blockade for Preventing Myocardial Ischemia/Reperfusion Injury and Remodeling after Myocardial Infarction
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Targeting phosphatidylinositol 3-kinase-Akt through hepatocyte growth factor for cardioprotection.
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  • Biology, Medicine
    Journal of cellular and molecular medicine
  • 2012
Old‐aged spontaneously hypertensive rats developed cardiac remodelling from hypertrophy to fibrosis via cardiac apoptosis during the end stage of hypertensive heart disease, and Rosuvastatin effectively attenuated the structural changes by reversing the signaling transductions involved.
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Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol.
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Reperfusion induces myocardial apoptotic cell death.
Involvement of CD95/Apo1/Fas in cell death after myocardial ischemia.
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Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo.
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