Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells.

@article{Fotoohi2008MechanismsOA,
  title={Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells.},
  author={Alan Kambiz Fotoohi and Freidoun Albertioni},
  journal={Leukemia & lymphoma},
  year={2008},
  volume={49 3},
  pages={410-26}
}
Antifolates are the first class of antimetabolites introduced to clinic about 6 decades ago. Now, after several years of administration of antifolates against malignancies and particularly leukemia, we are still trying to achieve a full understanding of the mechanisms of action and resistance to these agents. The present article covers different factors… CONTINUE READING