Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver.

@article{Piper1998MechanismsOA,
  title={Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver.},
  author={J. Piper and S. Singhal and M. Salameh and R. Torman and Y. Awasthi and S. Awasthi},
  journal={The international journal of biochemistry \& cell biology},
  year={1998},
  volume={30 4},
  pages={
          445-56
        }
}
Curcumin, an antioxidant isolated from turmeric (curcuma longa), has been shown to attenuate chemical carcinogenesis in rodents. Previous studies have shown that curcumin causes an increase in glutathione S-transferase (GST) activity in rodent liver which may contribute to its anti-cancer and anti-inflammatory activities. Since the effects of curcumin on specific GST isozymes and other glutathione (GSH)-linked enzymes are incompletely defined, we have examined in the present studies the effect… Expand
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