Mechanisms of antibody binding to a protein.

@article{Getzoff1987MechanismsOA,
  title={Mechanisms of antibody binding to a protein.},
  author={Elizabeth D. Getzoff and H. Mario Geysen and Stuart J Rodda and Hannah Alexander and John A. Tainer and Richard Allen Lerner},
  journal={Science},
  year={1987},
  volume={235 4793},
  pages={1191-6}
}
The mechanisms of antibody binding to a protein were studied by an analysis of specific amino acid residues critical to nine antigenic sites on myohemerythrin. Rabbit antisera to the whole protein were assayed for binding to more than 1500 distinct peptide analogs differing from the protein sequence by single amino acid replacements. The results, combined with information from the three-dimensional crystallographic structure, were used to evaluate probable mechanisms of antibody binding at… CONTINUE READING

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