Mechanisms of anti-inflammatory property of Anacardium occidentale stem bark: inhibition of NF-κB and MAPK signalling in the microglia.

@article{Olajide2013MechanismsOA,
  title={Mechanisms of anti-inflammatory property of Anacardium occidentale stem bark: inhibition of NF-κB and MAPK signalling in the microglia.},
  author={Olumayokun A Olajide and Mutalib A. Aderogba and Bernd L. Fiebich},
  journal={Journal of ethnopharmacology},
  year={2013},
  volume={145 1},
  pages={42-9}
}
ETHNOPHARMACOLOGICAL RELEVANCE Anacardium occidentale is used in traditional African medicine for the treatment of arthritis, fever, aches, pains, and inflammation of the extremities. AIM OF THE STUDY In this study, we investigated the molecular mechanisms responsible for anti-inflammatory effects of a stem bark extract of A. occidentale (ANE) in LPS-stimulated microglia. MATERIALS AND METHODS Nitric oxide (NO), prostaglandin E(2) and cytokine (TNFα and IL-6) production were evaluated in… CONTINUE READING