Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn.

@article{Brinc2009MechanismsOA,
  title={Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn.},
  author={Davor Brinc and Alan H Lazarus},
  journal={Hematology. American Society of Hematology. Education Program},
  year={2009},
  pages={185-91}
}
Anti-D is routinely and effectively used to prevent hemolytic disease of the fetus and newborn (HDFN) caused by the antibody response to the D antigen on fetal RBCs. Anti-D is a polyclonal IgG product purified from the plasma of D-alloimmunized individuals. The mechanism of anti-D has not been fully elucidated. Antigenic epitopes are not fully masked by anti-D and are available for immune system recognition. However, a correlation has frequently been observed between anti-D-mediated RBC… CONTINUE READING