Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions

@article{Sajib2017MechanismsOA,
  title={Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions},
  author={Sanaullah Sajib and Fatema Tuz Zahra and Michail S. Lionakis and Nadezhda A. German and Constantinos M. Mikelis},
  journal={Angiogenesis},
  year={2017},
  volume={21},
  pages={1-14}
}
Commensal microbiota inhabit all the mucosal surfaces of the human body. It plays significant roles during homeostatic conditions, and perturbations in numbers and/or products are associated with several pathological disorders. Angiogenesis, the process of new vessel formation, promotes embryonic development and critically modulates several biological processes during adulthood. Indeed, deregulated angiogenesis can induce or augment several pathological conditions. Accumulating evidence has… Expand
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References

SHOWING 1-10 OF 147 REFERENCES
Regulation of inflammation by microbiota interactions with the host
TLDR
The effects of the microbiome on innate and adaptive immunological players from epithelial cells and antigen-presenting cells to innate lymphoid cells and regulatory T cells are reviewed. Expand
Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis.
TLDR
The gut microbiota can selectively activate mucosal endothelial and mesenchymal cells to promote specific angiogenic responses in a TLR- and NOD-like receptor-dependent fashion and this innate immunity-mediated response may expand the mucosal microvascular network, foster immune cell recruitment, and contribute to chronic intestinal inflammation. Expand
El desarrollo vascular en la enfermedad inflamatoria intestinal
TLDR
Investigation into several growth factors and cytokines involved in vascular development could elucidate the role of vascular development in diseases whose pathogenesis involves chronic inflammation, such as inflammatory bowel disease. Expand
Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling
TLDR
It is shown that the gut microbiota promotes TF glycosylation associated with localization of TF on the cell surface, the activation of coagulation proteases, and phosphorylation of the TF cytoplasmic domain in the small intestine. Expand
Angiogenesis as a novel component of inflammatory bowel disease pathogenesis.
TLDR
Results provide morphological, phenotypic and functional evidence of potent angiogenic activity in both CD and UC mucosa, indicating that the local microvasculature undergoes an intense process of inflammation-dependent angiogenesis. Expand
Emerging cytokine networks in colorectal cancer
TLDR
How cancer mutations and epigenetic adaptations influence the oncogenic potential of cytokines is discussed, a relatively unexplored area that could yield crucial insights into tumour immunology and facilitate the effective application of cytokine-modulatory therapies for CRC. Expand
[Vascular development in inflammatory bowel disease].
TLDR
Investigation into several growth factors and cytokines involved in vascular development could elucidate the role of vascular development in diseases whose pathogenesis involves chronic inflammation, such as inflammatory bowel disease. Expand
Intestinal bacteria and the regulation of immune cell homeostasis.
TLDR
A review of the bacterial composition of the mammalian intestine, known bacterial-derived immunoregulatory molecules, and the mammalian innate immune receptors that recognize them and the mechanisms by which these signals modulate the development and progression of inflammatory disease. Expand
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
TLDR
Findings reveal a previously unappreciated mechanism of postnatal animal development, where microbes colonizing a mucosal surface are assigned responsibility for regulating elaboration of the underlying microvasculature by signaling through a bacteria-sensing epithelial cell. Expand
Epithelial-Mesenchymal Transitions in Development and Disease
TLDR
The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis. Expand
...
1
2
3
4
5
...