Mechanisms of amyloid formation revealed by solution NMR

@inproceedings{Karamanos2015MechanismsOA,
  title={Mechanisms of amyloid formation revealed by solution NMR},
  author={Theodoros K. Karamanos and Arnout P. Kalverda and Gary S. Thompson and Sheena E Radford},
  booktitle={Progress in nuclear magnetic resonance spectroscopy},
  year={2015}
}
Amyloid fibrils are proteinaceous elongated aggregates involved in more than fifty human diseases. Recent advances in electron microscopy and solid state NMR have allowed the characterization of fibril structures to different extents of refinement. However, structural details about the mechanism of fibril formation remain relatively poorly defined. This is mainly due to the complex, heterogeneous and transient nature of the species responsible for assembly; properties that make them difficult… CONTINUE READING

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