Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

@article{Edwards2015MechanismsOA,
  title={Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans},
  author={Clare B. Edwards and John Canfield and Neil Copes and Andres G. Brito and M. Rehan and David B Lipps and Jessica Brunquell and S. Westerheide and P. Bradshaw},
  journal={BMC Genetics},
  year={2015},
  volume={16}
}
BackgroundLittle is known about the role of amino acids in cellular signaling pathways, especially as it pertains to pathways that regulate the rate of aging. However, it has been shown that methionine or tryptophan restriction extends lifespan in higher eukaryotes and increased proline or tryptophan levels increase longevity in C. elegans. In addition, leucine strongly activates the TOR signaling pathway, which when inhibited increases lifespan.ResultsTherefore each of the 20 proteogenic amino… Expand
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