Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients.

@article{MillerGraziano1988MechanismsOA,
  title={Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients.},
  author={Carol L. Miller-Graziano and Melanie Fink and Jimmy Yiu-Cheong Wu and Gyongyi Szabo and Karen Kodys},
  journal={Archives of surgery},
  year={1988},
  volume={123 3},
  pages={293-9}
}
Monocytes from immunosuppressed trauma (11 patients) and burn (12 patients) patients stimulated with muramyl dipeptide, a potent prostaglandin E2 (PGE2) secretagogue, showed twofold greater PGE2 production compared with normal controls or immunocompetent patients. Monocyte plasminogen activator production was markedly depressed and inversely correlated to patients' monocyte hyper PGE2 production. Levels of the PGE2-producing monocyte subset (selected as high-affinity Fc+ receptors) were… CONTINUE READING