Mechanisms of allostery and membrane attachment in Ras GTPases: implications for anti-cancer drug discovery.

@article{Gorfe2010MechanismsOA,
  title={Mechanisms of allostery and membrane attachment in Ras GTPases: implications for anti-cancer drug discovery.},
  author={Alemayehu A. Gorfe},
  journal={Current medicinal chemistry},
  year={2010},
  volume={17 1},
  pages={
          1-9
        }
}
Ras GTPases are membrane-anchored molecular switches that mediate signaling pathways controlling a variety of cellular processes, including cell division and development. Despite their prominent role in many forms of cancer, little is known about the structure of the membrane bound protein or the mechanism and thermodynamics of membrane insertion. The… CONTINUE READING