Mechanisms of allosteric gene regulation by NMR quantification of microsecond-millisecond protein dynamics.

Abstract

The trp RNA-binding attenuation protein (TRAP) is a paradigmatic allosteric protein that regulates the tryptophan biosynthetic genes associated with the trp operon in bacilli. The ring-shaped 11-mer TRAP is activated for recognition of a specific trp-mRNA target by binding up to 11 tryptophan molecules. To characterize the mechanisms of tryptophan-induced… (More)
DOI: 10.1016/j.jmb.2011.11.019

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Cite this paper

@article{Kleckner2012MechanismsOA, title={Mechanisms of allosteric gene regulation by NMR quantification of microsecond-millisecond protein dynamics.}, author={Ian R. Kleckner and Paul D. Gollnick and Mark P. Foster}, journal={Journal of molecular biology}, year={2012}, volume={415 2}, pages={372-81} }