Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens.


Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a desensitizing therapy for IgE-mediated allergic diseases and represents a potentially curative way of treatment. The mechanisms of action of AIT include the induction of very early desensitization of mast cells and basophils; generation of regulatory T and regulatory B (Breg… (More)
DOI: 10.1016/j.jaci.2013.12.1088

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