Mechanisms of alcoholic liver injury.

  title={Mechanisms of alcoholic liver injury.},
  author={Samuel William French},
  journal={Canadian journal of gastroenterology = Journal canadien de gastroenterologie},
  volume={14 4},
There have been numerous recent advances in the understanding of the mechanisms of alcoholic liver disease pathogenesis. Endotoxin-induced Kupffer cell activation plays a role in cytokine-mediated inflammatory changes in the liver, and this can be blocked by a diet high in saturated fat, by a diet containing lactobacillus, which does not produce endotoxin, by neomycin antibiotic sterilization of the gut, by eliminating Kupffer cells, or by removing tumour necrosis factor-alpha with antibody or… CONTINUE READING
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