Mechanisms of airway hyperresponsiveness.

  title={Mechanisms of airway hyperresponsiveness.},
  author={Donald W. Cockcroft and Beth E. Davis},
  journal={The Journal of allergy and clinical immunology},
  volume={118 3},
  pages={551-9; quiz 560-1}
Airway hyperresponsiveness (AHR) to direct (histamine and methacholine) and indirect (exercise, cold air, hyperventilation, AMP) challenges is a universal and defining feature of asthma. One component of AHR is transient or inducible and occurs after allergen exposure, for example, and improves occasionally rapidly after inhaled corticosteroids or environmental control. This transient airway hyperresponsiveness is more marked to the indirect stimuli. There are convincing data linking this… CONTINUE READING
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