Mechanisms of aging in senescence-accelerated mice

  title={Mechanisms of aging in senescence-accelerated mice},
  author={Todd A. Carter and Jennifer A Greenhall and Shigeo Yoshida and Sebastian Fuchs and Robert Helton and Anand Swaroop and David J Lockhart and Carrolee Barlow},
  journal={Genome Biology},
  pages={R48 - R48}
Progressive neurological dysfunction is a key aspect of human aging. Because of underlying differences in the aging of mice and humans, useful mouse models have been difficult to obtain and study. We have used gene-expression analysis and polymorphism screening to study molecular senescence of the retina and hippocampus in two rare inbred mouse models of… CONTINUE READING