Mechanisms of adrenocorticotropin-induced activation of extracellularly regulated kinase 1/2 mitogen-activated protein kinase in the human H295R adrenal cell line.

@article{Janes2008MechanismsOA,
  title={Mechanisms of adrenocorticotropin-induced activation of extracellularly regulated kinase 1/2 mitogen-activated protein kinase in the human H295R adrenal cell line.},
  author={Mandy Elaine Janes and Ka Man Emily Chu and Adrian J. L. Clark and Peter James King},
  journal={Endocrinology},
  year={2008},
  volume={149 4},
  pages={
          1898-905
        }
}
The role of ACTH in stimulating or inhibiting growth of adrenal cells has been a subject of some controversy. Reports that ACTH may stimulate ERK/MAPK in Y1 cells have suggested a role for cAMP in this process. In attempting to extend this work, the ACTH responses in the human H295R cell line have been studied. This cell line makes only a very modest cAMP response to ACTH, yet the ERK1/2 response is highly reproducible and immediate but not prolonged. It is minimally reduced by the protein… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Human adrenocortical carcinoma cell lines

  • Molecular and Cellular Endocrinology
  • 2012
VIEW 15 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH.

  • Journal of molecular endocrinology
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

ACTH: The forgotten therapy.

  • Seminars in immunology
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

Development of adrenal cortex zonation.

  • Endocrinology and metabolism clinics of North America
  • 2015
VIEW 2 EXCERPTS
CITES BACKGROUND