Mechanisms of actions of opioids and non-steroidal anti-inflammatory drugs.

  • James G. Bovill
  • Published 1997 in European journal of anaesthesiology. Supplement
Opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are the commonest drugs used to treat pain. Opioids mimic the actions of endogenous opioid peptides by interacting with mu, delta or kappa opioid receptors. The opioid receptors are coupled to G1 proteins and the actions of the opioids are mainly inhibitory. They close N-type voltage-operated… CONTINUE READING