Mechanisms of action of rapamycin in gliomas.

  title={Mechanisms of action of rapamycin in gliomas.},
  author={Amy Heimberger and Enze Wang and Eric C McGary and Kenneth R. Hess and Verlene K Henry and Tadahisa Shono and Zvi Cohen and Joy Gumin and Raymond A Sawaya and Charles A. Conrad and Frederick F. Lang},
  volume={7 1},
Rapamycin has previously been shown to be efficacious against intracerebral glioma xenografts and to act in a cytostatic manner against gliomas. However, very little is known about the mechanism of action of rapamycin. The purpose of our study was to further investigate the in vitro and in vivo mechanisms of action of rapamycin, to elucidate molecular end points that may be applicable for investigation in a clinical trial, and to examine potential mechanisms of treatment failure. In the… CONTINUE READING
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