Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche

@article{Mazhari2007MechanismsOA,
  title={Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche},
  author={Ramesh Mazhari and Joshua M Hare},
  journal={Nature Clinical Practice Cardiovascular Medicine},
  year={2007},
  volume={4 Suppl 1},
  pages={S21-S26}
}
Clinical and basic studies of cell-based myocardial therapy have proceeded at a rapid pace. Cell therapy could lead to successful cardiac regeneration or repair by any of three general mechanisms: differentiation of the administered cells into all of the cellular constituents of the heart; release of factors capable of paracrine signaling from the administered cells; and fusion of the administered cells with the existing constituents of the heart. Here, we argue that a fourth general mechanism… CONTINUE READING
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Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation

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