Mechanisms of action of lidocaine and quinidine on action potential duration in rabbit cardiac Purkinje fibers. An effect on steady state sodium currents?

@article{Colatsky1982MechanismsOA,
  title={Mechanisms of action of lidocaine and quinidine on action potential duration in rabbit cardiac Purkinje fibers. An effect on steady state sodium currents?},
  author={Thomas J. Colatsky},
  journal={Circulation research},
  year={1982},
  volume={50 1},
  pages={17-27}
}
The effects of lidocaine and quinidine on rabbit cardiac Purkinje fibers were compared at 37 °C, using action potential and voltage clamp measurements. At therapeutic concentrations (5 /ig/ml), lidocaine shortened the duration of the action potential while quinidine lengthened it. When membrane potential was held constant between —40 and —50 mV by the application of the two-microelectrode voltage clamp, holding current consistently became more outward with lidocaine (+2.3 ± 0.7 nA, mean ± SEM… CONTINUE READING

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Actions of lidocaine, quinidine and tetrodotoxin on membrane currents underlying the cardiac action potential plateau (abstr)

  • TJ Colatsky
  • Biophys J
  • 1981
1 Excerpt

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