Mechanisms of action of isoniazid

@article{Timmins2006MechanismsOA,
  title={Mechanisms of action of isoniazid},
  author={Graham S Timmins and Vojo Deretic},
  journal={Molecular Microbiology},
  year={2006},
  volume={62}
}
For decades after its introduction, the mechanisms of action of the front‐line antituberculosis therapeutic agent isoniazid (INH) remained unclear. Recent developments have shown that peroxidative activation of isoniazid by the mycobacterial enzyme KatG generates reactive species that form adducts with NAD+ and NADP+ that are potent inhibitors of lipid and nucleic acid biosynthetic enzymes. A direct role for some isoniazid‐derived reactive species, such as nitric oxide, in inhibiting… 
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TLDR
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TLDR
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TLDR
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TLDR
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Update of Antitubercular Prodrugs from a Molecular Perspective: Mechanisms of Action, Bioactivation Pathways, and Associated Resistance
TLDR
Identification of the prodrugs targets and a better understanding of their modes of action and also of their activation mechanisms are of crucial importance, as well as the reported resistance related to these mechanisms of activation/action.
Isoniazid: Radical-induced oxidation and reduction chemistry.
Acetylation of Isoniazid Is a Novel Mechanism of Isoniazid Resistance in Mycobacterium tuberculosis
TLDR
Results strongly indicate that Rv2170 acetylates INH, and this could be one of the strategies adopted by at least some M. tuberculosis strains to overcome INH toxicity, although this needs to be tested in INH-resistant clinical strains.
Mechanisms of isoniazid‐induced idiosyncratic liver injury: Emerging role of mitochondrial stress
TLDR
This review discusses these emerging new paradigms of INH‐induced DILI and highlights recent insights into the mechanisms, as well as points to the existing large gaps in the understanding of the pathogenesis.
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