Mechanisms of action of fluvoxamine for COVID-19: a historical review

@article{Hashimoto2022MechanismsOA,
  title={Mechanisms of action of fluvoxamine for COVID-19: a historical review},
  author={Yaeko Hashimoto and Takuji Suzuki and Kenji Hashimoto},
  journal={Molecular Psychiatry},
  year={2022},
  volume={27},
  pages={1898 - 1907}
}
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of prophylactic and therapeutic drugs for persons infected with the virus. Drug repurposing for the COVID-19 pandemic has received particular attention. Increasing clinical data suggest that antidepressant use in early-stage subjects with COVID-19 might be associated with a reduced risk of intubation or death. Among the… 
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A review on drug repurposing in COVID-19: from antiviral drugs to herbal alternatives
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11 repurposing drugs, their positive and negative health implications, along with traditional herbal alternatives, that harvest strong potential in efficient treatments options against COVID-19, with small or no significant side effects are summarized.
Difficulty in Repurposing Selective Serotonin Reuptake Inhibitors and Other Antidepressants with Functional Inhibition of Acid Sphingomyelinase in COVID-19 Infection
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Some prematurely optimistic points of view, promoting a large prescription of fluvoxamine in patients with COVID-19, are thought to be reasonably tempered.
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There are no therapeutic drugs for long-term symptoms in survivors of COVID-19 and the most common sequelae neurologic headaches, neurological headaches, and functional mobility impairment are found.
Deleterious effects of nervous system in the offspring following maternal SARS-CoV-2 infection during the COVID-19 pandemic
TLDR
This review summarizes the possible mechanisms of the nervous system effects of SARS-CoV-2 infection on their offspring during the pregnancy and analyzes the available prophylactic and treatment strategies to improve the prognosis of fetal-related neuropsychiatric diseases after birth.
Antidepressants for COVID-19: A systematic review
Post-COVID-19 Depressive Symptoms: Epidemiology, Pathophysiology, and Pharmacological Treatment
TLDR
This paper reviews the current literature and synthesizes the available evidence regarding epidemiology, clinical features, neurobiological underpinning, and pharmacological treatment of post-COVID-19 depressive symptoms to counteract the depression disease burden and related years of life lived with disability.
COVID-19 and its clinical severity are associated with alterations of plasma sphingolipids and enzyme activities of sphingomyelinase and ceramidase
TLDR
COVID-19 is associated with a dysregulation of sphingolipid homeostasis in a severity-dependent manner and an accumulation of ceramides by increased enzyme activities leading to ceramide elevation (ASM, NSM) combined with a decreased activity of enzymes (NC) reducing ceramide levels.
The effect of antidepressants on severity of COVID-19 in hospitalized patients: A systematic review and meta-analysis
TLDR
Most of the evidence supports that the use of antidepressant medications, mainly Fluvoxamine may decrease the severity and improve the outcome in hospitalizes patients with sars-cov-2.
Fluvoxamine and long COVID-19; a new role for sigma-1 receptor (S1R) agonists
TLDR
It inhibits acid sphingomyelinase activity, the formation of ceramide-enriched membrane domain, and attenuates SARS-CoV-2 cell entry and a potent sigma-1 receptor (S1R) agonist may SARS-CoVs endoplasmic reticulum stress ammation.
Recent Advances in Influenza, HIV and SARS-CoV-2 Infection Prevention and Drug Treatment—The Need for Precision Medicine
TLDR
The views on vaccination and pharmacotherapy, their mutually reinforcing strategic significance in combating pandemics, and the pros and cons of host and virus-targeted drug therapy are shared.
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