Mechanisms of action of docosahexaenoic acid in the nervous system

@article{Salem2001MechanismsOA,
  title={Mechanisms of action of docosahexaenoic acid in the nervous system},
  author={Norman Salem and Burton J. Litman and Hee-Yong Kim and Klaus Gawrisch},
  journal={Lipids},
  year={2001},
  volume={36},
  pages={945-959}
}
AbtractThis review describes (from both the animal and human literature) the biological consequences of losses in nervous system docosahexaenoate (DHA). It then concentrates on biological mechanisms that may serve to explain changes in brain and retinal function. Brief consideration is given to actions of DHA as a nonesterified fatty acid and as a docosanoid or other bioactive molecule. The role of DHA-phospholipids in regulating G-protein signaling is presented in the context of studies with… 
[The role of docosahexaenoic acid in neuronal function].
TLDR
The results of high DHA content in neuronal membranes and formation of DHA derivates, as well as the function of D HA-dependent phosphatidylserine, may explain the promising results supporting beneficial DHA supplementation in neurodegenerative diseases and improvement of brain function.
Biochemical and biological functions of docosahexaenoic acid in the nervous system: modulation by ethanol.
  • Hee-Yong Kim
  • Biology, Medicine
    Chemistry and physics of lipids
  • 2008
Molecular and Signaling Mechanisms for Docosahexaenoic Acid-Derived Neurodevelopment and Neuroprotection
TLDR
The DHA status in the brain influences not only the PS-dependent signal transduction but also the metabolite formation and expression of pre- and post-synaptic proteins that are downstream of the CREB and affect neurotransmission.
Docosahexaenoic acid,22:6n-3: Its roles in the structure and function of the brain
Effects of docosapentaenoic acid on neuronal apoptosis
TLDR
The data suggest that depletion of DHA from neuronal tissues may have a compounding effect on Raf-1 translocation in growth factor signaling and the fact that DPA cannot fully support the protective role played by DHA may provide a basis for the adverse effect of n−3 FA deficiency on neuronal development and function.
Novel Metabolism of Docosahexaenoic Acid in Neural Cells*
TLDR
In this review, biochemical mechanisms for enriching and metabolizing DHA in neural cells are discussed in the context of their biological significance in neuronal function.
Docosahexaenoic acid affects cell signaling by altering lipid rafts.
TLDR
The uptake of DHA into brain phosphatidylethanolamines and the subsequent exclusion of cholesterol from the DHA-rich membranes is reported and a proposal of how DHA incorporation into membranes may control cell biochemistry and physiology is proposed.
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