Mechanisms of action of cyclic nucleotides on a bursting pacemaker and silent neuron in Aplysia.

@article{Drake1981MechanismsOA,
  title={Mechanisms of action of cyclic nucleotides on a bursting pacemaker and silent neuron in Aplysia.},
  author={P F Drake and Steven N. Treistman},
  journal={Brain research},
  year={1981},
  volume={218 1-2},
  pages={243-54}
}
Cyclic nucleotides are believed to mediate a long-lasting synaptic hyperpolarization in the bursting pacemaker neuron, R15, and are capable of inducing bursting pacemaker activity in the usually silent metacerebral giant cell. Steady state voltage clamp techniques were used to examine the alterations of membrane characteristics produced in these different cell types by cyclic nucleotides. In both cells, IBMX, a phosphodiesterase inhibitor, increased two components: (1) voltage-dependent sodium… CONTINUE READING